Journal of Biomedical Optics, September/October 2009
J. Biomed. Opt. 14, 050504 (2009) (3 pages)
©2009 Society of Photo-Optical Instrumentation Engineers. All rights reserved.
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Doppler optical microangiography improves the quantification of local fluid flow and shear stress within 3-D porous constructs
Yali Jia,
Lin An, and
Ruikang K. Wang†
Oregon Health & Science University, Department of Biomedical Engineering, 3303 South West Bond Avenue, Portland, Oregon 97239
(Received: 9 June 2009; revised: 23 July 2009; accepted: 25 July 2009; published online: 7 October 2009)Traditional phase-resolved Doppler optical coherence tomography (DOCT) has been reported to have potential for characterizing local fluid flow within a microporous scaffold. In this work, we apply Doppler optical microangiography (DOMAG), a new imaging technique developed by combining optical microangiography (OMAG) with a phase-resolved method, for improved assessment of local fluid flow and its derived parameters, shear stress, and interconnectivity, within highly scattering porous constructs. Compared with DOCT, we demonstrate a dramatic improvement of DOMAG in quantifying flow-related properties within scaffolds in situ for functional tissue engineering. ©2009 Society of Photo-Optical Instrumentation Engineers
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