Journal of Biomedical Optics, September/October 2009
J. Biomed. Opt. 14, 050503 (2009) (3 pages)
©2009 Society of Photo-Optical Instrumentation Engineers. All rights reserved.
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JBO Letters
Optical investigation of diffusion of levofloxacin mesylate in agarose hydrogel
Shuaixia Tan,1,2
Hongjun Dai,1,2
Juejie Wu,1,3
Ning Zhao,1 †
Xiaoli Zhang,1 and
Jian Xu1 †
1Institute of Chemistry Chinese Academy of Sciences, Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, Beijing 100190, China
2Graduate University of the Chinese Academy of Sciences, Beijing 100190, China
3Xiangtan University, College of Chemistry, Xiangtan, Hunan 411105, China
(Received: 17 April 2009; revised: 26 June 2009; accepted: 19 July 2009; published online: 1 October 2009)Real-time electronic speckle pattern interferometry method has been applied to study the diffusion behavior of levofloxacin mesylate (MSALVFX) in agarose hydrogel. The results show that the diffusivity of solute decreases with the increase of concentration of agarose and adapts to Kohlrausch's law. Furthermore, Amsden's model, based on the retardance effect associated with polymer chain flexibility, was employed to simulate the diffusion behavior. The consistent results suggest that the retardance effect dominates the diffusion process of MSALFVX in hydrogel; moreover, polymer chain flexibility greatly affects drug transport within the polymer matrix. ©2009 Society of Photo-Optical Instrumentation Engineers
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