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Effects of CO2 and HeNe laser radiation on rat sciatic nerve in vitro
Isolated rat sciatic nerve was exposed to 10.6 and 0.622 un laser radiation in a plexiglass chamber perfused withKrebs solution. A LS88OE Surgical Laser System supplied the laser beam which was aimed ...
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Simulation of ablation and thermal damage in CO2 laser-irradiated tissue
A previously described numerical model which calculates heat transfer in biological tissue exposed toCo2 laser irradiation was adapted and applied to predict the amount of ablated tissue and periphera...

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Pulsed delivery of laser energy in experimental thermal retinal photocoagulation

Proc. SPIE, Vol. 1202, 205 (1990); doi:10.1117/12.17626

Online Publication Date: 17 May 2005

Conference Date: Monday 15 January 1990
Conference Location: Los Angeles, CA, USA
Conference Title: Laser-Tissue Interaction
Conference Chairs: Steven L. Jacques
Michail M. Pankratov
Eye Research Institute and Lahey Clinic Medical Ctr. (USA)
Retinal lesions produced with a pulsed laser beam of 1-20 kHz frequency and 10-100% duty cycle were comparedwith lesions produced with a continuous wave (cw) laser of the same peak power and total energy. Photocoagulation wasapplied to the retina of three black pigmented rabbits using krypton red laser (647.1 nm) equipped with an acousto-opticalmodulator to convert cw laser emission to a pulsating beam. An optical fiber fed the laser beam into an optical systemdelivering a collimated beam of predetermined divergence; the animal's eye focused this beam to a 50-pm spot on the retina.Peak power was kept constant at 0.2 W, and energy was kept constant at 20 mJ. After 7 months the animals were sacrificedand retinal tissue examined by light microscopy. The central section of each lesion was identified and photographed. Forlesions with the same energy per pulse and the same pulse duration, the most influential factor, in the frequency range of 1-20kHz, appeared to be the duty cycle: the smaller the duty cycle, the smaller the lesion, and vice versa. In other words, theshorter the time interval between consecutive pulses, the larger were the pulsed laser lesions.

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