Effects of CO2 and HeNe laser radiation on rat sciatic nerve in vitro
Isolated rat sciatic nerve was exposed to 10.6 and 0.622 un laser radiation in a plexiglass chamber perfused withKrebs solution. A LS88OE Surgical Laser System supplied the laser beam which was aimed ...
Simulation of ablation and thermal damage in CO2 laser-irradiated tissue
A previously described numerical model which calculates heat transfer in biological tissue exposed toCo2 laser irradiation was adapted and applied to predict the amount of ablated tissue and periphera...
Pulsed delivery of laser energy in experimental thermal retinal photocoagulation
Proc. SPIE, Vol. 1202, 205 (1990);
doi:10.1117/12.17626
Online Publication Date: 17 May 2005
Conference Date: Monday 15 January 1990
Conference Location: Los Angeles, CA, USA
Conference Title: Laser-Tissue Interaction
Conference Chairs: Steven L. Jacques
Retinallesions produced with a pulsed laser beam of 1-20 kHzfrequency and 10-100% duty cycle were comparedwith lesions produced witha continuous wave (cw) laser of the same peak powerand total energy. Photocoagulation wasapplied to the retina of threeblack pigmented rabbits using krypton red laser (647.1 nm) equippedwith an acousto-opticalmodulator to convert cw laser emission to apulsating beam. An optical fiber fed the laser beam intoan optical systemdelivering a collimated beam of predetermined divergence; theanimal's eye focused this beam to a 50-pm spot onthe retina.Peak power was kept constant at 0.2 W, andenergy was kept constant at 20 mJ. After 7 monthsthe animals were sacrificedand retinal tissue examined by light microscopy.The central section of each lesion was identified and photographed.Forlesions with the same energy per pulse and the samepulse duration, the most influential factor, in the frequency rangeof 1-20kHz, appeared to be the duty cycle: the smallerthe duty cycle, the smaller the lesion, and vice versa.In other words, theshorter the time interval between consecutive pulses,the larger were the pulsed laser lesions.