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J. Biomed. Opt. / Volume 14 / Issue 5 / JBO Letters

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Optical investigation of diffusion of levofloxacin mesylate in agarose hydrogel

J. Biomed. Opt., Vol. 14, 050503 (2009); doi:10.1117/1.3227034

Published 1 October 2009

ABSTRACT

REFERENCES (8)

Shuaixia Tan,^1,2 Hongjun Dai,^1,2 Juejie Wu,^1,3 Ning Zhao,¹ Xiaoli Zhang,¹ and Jian Xu¹
¹Institute of Chemistry Chinese Academy of Sciences, Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, Beijing 100190, China
²Graduate University of the Chinese Academy of Sciences, Beijing 100190, China
³Xiangtan University, College of Chemistry, Xiangtan, Hunan 411105, China

Real-timeelectronic speckle pattern interferometry method has been applied to studythe diffusion behavior of levofloxacin mesylate (MSALVFX) in agarose hydrogel.The results show that the diffusivity of solute decreases withthe increase of concentration of agarose and adapts to Kohlrausch'slaw. Furthermore, Amsden's model, based on the retardance effect associatedwith polymer chain flexibility, was employed to simulate the diffusionbehavior. The consistent results suggest that the retardance effect dominatesthe diffusion process of MSALFVX in hydrogel; moreover, polymer chainflexibility greatly affects drug transport within the polymer matrix.

©2009 Society of Photo-Optical Instrumentation Engineers

History:	Received 17 April 2009; revised 26 June 2009; accepted 19 July 2009; published 1 October 2009
DOI Link:	http://dx.doi.org/10.1117/1.3227034

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KEYWORDS and PACS

Keywords

biomedical materials, biotransport, diffusion, drug delivery systems, molecular biophysics, polymer gels

PACS

87.85.J-
Biomaterials (biomedical engineering)
87.15.-v
Biomolecules: structure and physical properties
YEAR: 2009

JOURNAL DATA

ISSN:

1083-3668 (print) 1560-2281 (online)

Publisher:

SPIE

REFERENCES (8)

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