Corneal birefringence compensation for polarization sensitive optical coherence tomography of the human retina
In previous publications we have reported on polarization-sensitive optical coherence tomography (PS-OCT) systems that measure and image retardation and axis orientation of birefringent samples with o...
Spectral oximetry assessed with high-speed ultra-high-resolution optical coherence tomography
We use Fourier domain optical coherence tomography (OCT) data to assess retinal blood oxygen saturation. Three-dimensional disk-centered retinal tissue volumes were assessed in 17 normal healthy subje...
Three-dimensional optical coherence tomography at 1050 nm versus 800 nm in retinal pathologies: enhanced performance and choroidal penetration in cataract patients
J. Biomed. Opt., Vol. 12, 041211 (2007);
doi:10.1117/1.2773728
Published 11 September 2007
ABSTRACT
REFERENCES (33)
CITING ARTICLES
Boris Považay, Boris Hermann, Angelika Unterhuber, and Bernd Hofer Cardiff University, School of Optometry and Vision Sciences, Biomedical Imaging Group, Cardiff, Wales, CF24 4LU, United Kingdom and Medical University of Vienna, Center for Biomedical Engineering and Physics, Waehringerstrasse 13, Vienna, A-1090, Vienna, Austria
Harald Sattmann Medical University of Vienna, Center for Biomedical Engineering and Physics, Waehringerstrasse 13, Vienna, A-1090, Vienna, Austria
Florian Zeiler Rudolf Foundation Clinic Vienna, Department of Ophthalmology, Ludwig Boltzmann Institute, Juchgasse 25, Vienna, A-1030, Vienna, Austria
James E. Morgan Cardiff University, School of Optometry and Vision Science 1, Biomedical Imaging Group, Cardiff, Wales, CF24 4LU, United Kingdom
Wolfgang Drexler Cardiff University, School of Optometry and Vision Science 1, Biomedical Imaging Group, Cardiff, Wales, CF24 4LU, United Kingdom and Medical University of Vienna, Center for Biomedical Engineering and Physics, Waehringerstrasse 13, Vienna, A-1090, Vienna, Austria
Frequencydomain optical coherence tomography (FD-OCT), based on an all-reflective high-speedInGaAs spectrometer, operating in the 1050 nm wavelength region for retinaldiagnostics, enables high-speed, volumetric imaging of retinal pathologies with greaterpenetration into choroidal tissue is compared to conventional 800 nm three-dimensional(3-D) ophthalmic FD-OCT systems. Furthermore, the lower scattering at thiswavelength significantly improves imaging performance in cataract patients, thereby wideningthe clinical applicability of ophthalmic OCT. The clinical performance oftwo spectrometer-based ophthalmic 3-D OCT systems compared in respect totheir clinical performance, one operating at 800 nm with 150 nm bandwidth(~3 µm effective axial resolution) and the other at 1050 nm with70 nm bandwidth (~7 µm effective axial resolution). Results achieved with 3-DOCT at 1050 nm reveal, for the first time, decisive improvementsin image quality for patients with retinal pathologies and clinicallysignificant cataract.
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