Dynamic analysis of chemical eye burns using high-resolution optical coherence tomography
The use of high-resolution optical coherence tomography (OCT) to visualize penetration kinetics during the initial phase of chemical eye burns is evaluated. The changes in scattering properties and th...
Autocalibration of spectral-domain optical coherence tomography spectrometers for in vivo quantitative retinal nerve fiber layer birefringence determination
Accurate wavelength assignment of each spectral element for spectral-domain optical coherence tomography (SD-OCT) and optical frequency domain imaging (OFDI) is required for proper construction of bio...
Minimum distance mapping using three-dimensional optical coherence tomography for glaucoma diagnosis
J. Biomed. Opt., Vol. 12, 041204 (2007);
doi:10.1117/1.2773736
Published 10 September 2007
ABSTRACT
REFERENCES (27)
Boris Považay, Bernd Hofer, Boris Hermann, and Angelika Unterhuber Cardiff University, School of Optometry and Vision Sciences, Biomedical Imaging Group, Cardiff, Wales CF24 4LU, United Kingdom and Medical University of Vienna, Center for Biomedical Engineering and Physics, Waehringerstrasse 13, Vienna A-1090, Austria
James E. Morgan Cardiff University, School of Optometry and Vision Sciences, Biomedical Imaging Group, Cardiff, Wales CF24 4LU, United Kingdom
Carl Glittenberg and Susanne Binder Rudolf Foundation Clinic Vienna, Department of Ophthalmology, Ludwig Boltzmann Institute, Vienna A-1090, Austria
Wolfgang Drexler Cardiff University, School of Optometry and Vision Sciences, Biomedical Imaging Group, Cardiff, Wales CF24 4LU, United Kingdom and Medical University of Vienna, Center for Biomedical Engineering and Physics, Waehringerstrasse 13, Vienna A-1090, Austria
Objectiveimaging of the optic nerve structure has become central tothe management of patients with glaucoma. There is an urgentneed in diagnosis and staging for reliable objective precursors andmarkers. Three-dimensional ultrahigh-resolution frequency domain optical coherence tomography (3D UHROCT) holds particular promise in this respect since it enablesvolumetric assessment of intraretinal layers including tomographic data for theretinal nerve fiber layer (RNFL) and optic nerve head. Theintegrated analysis of this information and the resolution advantage hasenabled the development of more informative indices of axonal damagein glaucoma compared with measurements of RNFL thickness and cup-to-discratio provided by commercial OCT devices. The potential for UHROCT in enabling the combined analysis of tomographic and volumetricdata on retinal structure is explored. A novel parameter wasdeveloped; the three-dimensional minimal distance as the optical correlate oftrue retinal nerve fiber layer thickness around the optic nervehead region. For the purposes of this pilot study, wepresent data from a normal subject and from two patientswith characteristic optic nerve and retinal nerve fiber layer changessecondary to glaucoma.
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