Comparison between a time-domain and a frequency-domain system for optical tomography
The quality of phase and amplitude data from two medical optical tomography systems were compared. The two systems are a 32-channel time-domain system developed at University College London (UCL) and ...
Time-resolved imaging of optical coefficients through murine chest cavities
As small animal optical imaging and tomography are gaining popularity for interrogating functional and molecular events in vivo, it becomes increasingly necessary to gain knowledge of the optical prop...
Compression-induced changes in the physiological state of the breast as observed through frequency domain photon migration measurements
J. Biomed. Opt., Vol. 11, 064016 (2006);
doi:10.1117/1.2397572
Published 18 December 2006
ABSTRACT
REFERENCES (18)
CITING ARTICLES
Stefan A. Carp, Tina Kauffman, and Qianqian Fang Harvard Medical School, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129
David Boas Harvard Medical School, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129
Weuse optical spectroscopy to characterize the influence of mammographic-like compressionon the physiology of the breast. We note a reductionin total hemoglobin content, tissue oxygen saturation, and optical scatteringunder compression. We also note a hyperemic effect during repeatedcompression cycles. By modeling the time course of the tissueoxygen saturation, we are able to obtain estimates for thevolumetric blood flow (1.64±0.6 mL/100 mL/min) and the oxygen consumption (1.97±0.6 µmol/100 mL/min) ofcompressed breast tissue. These values are comparable to estimates obtainedfrom previously published positron emission tomography (PET) measurements. We concludethat compression-induced changes in breast physiological properties are significant andshould be accounted for when performing optical breast imaging. Additionally,the dynamic characteristics of the changes in breast physiological parameters,together with the ability to probe the tissue metabolic state,may prove useful for breast cancer detection.
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