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Reliability of the compensation comparison stray-light measurement method

J. Biomed. Opt., Vol. 11, 034027 (2006); doi:10.1117/1.2209555

Published 7 June 2006
Joris E. Coppens and Luuk Franssen
Netherlands Ophthalmic Research Institute, Amsterdam, Netherlands

L. J. van Rijn
Vrije Universiteit Medical Centre, Amsterdam, Netherlands

Thomas J. T. P. van den Berg
Netherlands Ophthalmic Research Institute, Amsterdam, Netherlands
The compensation comparison (CC) method is a psychophysical technique to measure retinal stray light. It uses a two alternative forced choice (2AFC) measurement paradigm. The 25 binary (0 and 1) responses resulting from the 2AFC test are analyzed using maximum likelihood estimates. The likelihood function is used to give two quantities: the most likely stray-light level of the eye under investigation, and the accuracy of this estimate [called expected standard deviation (ESD)]. The CC method is used in 2422 subjects of the GLARE study. Each eye is tested twice to allow analysis of measurement repeatability. Furthermore, the large amount of responses is used to evaluate the shape of the psychometric function, for which a mathematical model is used. The shape of the psychometric function found by averaging the 0 and 1 responses fit well to the model function. Data sorted according to ESD show differences in the shape of the psychometric function between good and bad observers. These different shapes for the psychometric function are used to reanalyze the data, but the stray-light results remain virtually identical. ESD proves to be an efficient tool to detect unreliable measurements. In clinical practice, ESD may be used to decide whether to repeat a measurement.

©2006 Society of Photo-Optical Instrumentation Engineers
History: Received 23 September 2005; revised 3 January 2006; accepted 4 January 2006; published 7 June 2006
DOI Link: http://dx.doi.org/10.1117/1.2209555
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KEYWORDS and PACS

Keywords
PACS
  • 42.66.Ct
    Anatomy and optics of eye
  • 42.66.Si
    Psychophysics of vision, visual perception; binocular vision
  • 87.19.Dd
    Information processing in vision and hearing
  • 02.50.-r
    Probability theory, stochastic processes, and statistics
  • YEAR: 2006

JOURNAL DATA

ISSN:
1083-3668 (print)   1560-2281 (online)
Publisher:
AIP is a member of CrossRef SPIE

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