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BRAIN I

Near-infrared spectroscopy of the human brain during electroconvulsive therapy
Sergio Fantini, Francesco Fabbri, Shalini Nadgir, Michael E. Henry, Perry F. Renshaw, and Maria-Angela Franceschini
pp. 1-5
Abstract     Full Text:  [  PDF (364 kB)  ]

Validation of the use of homogeneous reference phantoms for optical tomography of the neonatal brain
Rozarina M. Yusof, Jeremy C. Hebden, Adam Gibson, Nick Everdell, Topun Austin, Judith H. Meek, Simon R. Arridge, John S. Wyatt, and David T. Delpy
pp. 6-11
Abstract     Full Text:  [  PDF (121 kB)  ]

Optical tomographic brain imaging with diffusion and transport-theory-based algorithms
Andreas H. Hielscher, Gassan S. Abdoulaev, Avraham Y. Bluestone, Joseph Lasker, and Alexander D. Klose
pp. 12-21
Abstract     Full Text:  [  PDF (464 kB)  ]

In vivo simultaneous cortical and intracortical monitoring of cerebral blood flow and mitochondrial redox state in experimental animals
E. Barbiro-Michaely, T. Zuckerman, N. Zarchin, S. Rinkevich, N. Knoller, M. Hadani, and A. Mayevsky
pp. 22-30
Abstract     Full Text:  [  PDF (149 kB)  ]

THEORY I

Signal source separation and localization in the analysis of dynamic near-infrared optical tomographic time series
Harry L. Graber, Yaling Pei, Randall L. Barbour, David K. Johnston, Ying Zheng, and John E. Mayhew
pp. 31-51
Abstract     Full Text:  [  PDF (3528 kB)  ]

Three-dimensional simultaneous absorption and scattering coefficient reconstruction for reflection geometry
Minming Huang, Nan Guang Chen, Baohong Yuan, and Quing Zhu
pp. 52-58
Abstract     Full Text:  [  PDF (171 kB)  ]

Benefits of vectorization in optical tomography
Margaret J. Eppstein and Jeffrey P. Laible
pp. 59-69
Abstract     Full Text:  [  PDF (199 kB)  ]

BREAST I

Breast lesion diagnosis using combined near-infrared diffusive light and ultrasound: initial clinical results
Quing Zhu, Scott Kurtzman, Minming Huang, Nan Guang Chen, Kristen Zarfos, Bipin Jagjivan, and Mark Kane
pp. 70-83
Abstract     Full Text:  [  PDF (499 kB)  ]

Time-frequency analysis of functional optical mammographic images
Randall L. Barbour, Harry L. Graber, Christoph H. Schmitz, Frank Tarantini, Georges Khoury, David J. Naar, Thomas F. Panetta, Theophilus Lewis, and Yaling Pei
pp. 84-95
Abstract     Full Text:  [  PDF (1327 kB)  ]

BRAIN II

Functional imaging of the brain using a portable NIR instrument
Tharshan Vaithianathan, Iain D. C. Tullis, Nicholas Everdell, Terence Leung, Judith Meek, and David T. Delpy
pp. 96-102
Abstract     Full Text:  [  PDF (360 kB)  ]

Feasibility of NIR tomographic reconstruction with multispectral continuous wave data by mapping into frequency domain data
Heng Xu, Brian W. Pogue, Hamid Dehghani, Roger Springett, Keith D. Paulsen, and Jeffrey F. Dunn
pp. 103-114
Abstract     Full Text:  [  PDF (287 kB)  ]

Three-dimensional optical tomographic brain imaging during hypercapnia in rodents
Avraham Y. Bluestone, Mark Stewart, Joseph Lasker, Gassan S. Abdoulaev, and Andreas H. Hielscher
pp. 115-123
Abstract     Full Text:  [  PDF (502 kB)  ]

Near-infrared measurements of hemodynamic and oxygenation changes on the frontal cortex during breath holding, hyperventilation, and natural sleep
Tommi E. Noponen, Kalle Kotilahti, Jussi Toppila, Ilkka T. Nissila, Tapani Salmi, Timo T. Kajava, and Toivo E. Katila
pp. 124-133
Abstract     Full Text:  [  PDF (1448 kB)  ]

Optical topographic studies of adults and neonates
Ilkka T. Nissila, Kalle Kotilahti, Tommi E. Noponen, Minna Huotilainen, Risto Naatanen, and Toivo E. Katila
pp. 134-144
Abstract     Full Text:  [  PDF (890 kB)  ]

INSTRUMENTATION I

Animal imaging using immersion
Konstantinos S. Kalogerakis, Kenneth T. Kotz, Kendra Rand, and Gregory W. Faris
pp. 145-153
Abstract     Full Text:  [  PDF (116 kB)  ]

Comparison of two time-resolved detectors for diffuse optical tomography: photomultiplier tube--time-correlated single photon counting and multichannel streak camera
Patrick Poulet, Chantal V. Zint, Murielle Torregrossa, Wilfried Uhring, and Bernard Cunin
pp. 154-163
Abstract     Full Text:  [  PDF (373 kB)  ]

Hemodynamic measurements in rat brain and human muscle using diffuse near-infrared absorption and correlation spectroscopies
Guoqiang Yu, Turgut Durduran, D. Furuya, G. Lech, Chao Zhou, Britten Chance, J. H. Greenberg, and Arjun G. Yodh
pp. 164-174
Abstract     Full Text:  [  PDF (495 kB)  ]

Portable multichannel multiwavelength near-infrared diffusive light imager
Nan Guang Chen, Hongjun Xia, Daqing Piao, and Quing Zhu
pp. 175-182
Abstract     Full Text:  [  PDF (105 kB)  ]

BREAST II

Optical mammography with single-wavelength contrast enhancement and multiwavelength oxygenation assessment
Sergio Fantini, Erica L. Heffer, Vivian E. Pera, Sylvia Heywang-Koebrunner, Linda Goetz, Anke Heinig, Oliver Schuetz, and Horst Siebold
pp. 183-190
Abstract     Full Text:  [  PDF (326 kB)  ]

Optical images from pathophysiological signals within breast tissue using three-dimensional near-infrared light
Hamid Dehghani, Brian W. Pogue, Shudong Jiang, Steven P. Poplack, and Keith D. Paulsen
pp. 191-198
Abstract     Full Text:  [  PDF (640 kB)  ]

Cancerous and normal human tissues investigated by near-infrared time-resolved and spectroscopic imaging techniques
Mohammad Alrubaiee, Swapan K. Gayen, Jason A. Koutcher, and Robert R. Alfano
pp. 199-202
Abstract     Full Text:  [  PDF (146 kB)  ]

Four-wavelength time-resolved optical mammograph
Rinaldo Cubeddu, Gian Maria Danesini, Fabrizio Messina, Antonio Pifferi, Lorenzo Spinelli, Paola Taroni, and Alessandro Torricelli
pp. 203-210
Abstract     Full Text:  [  PDF (223 kB)  ]

FLUORESCENCE I

Advances in 3D frequency domain fluorescence tomography
Margaret J. Eppstein, Chaoyang Zhang, Anuradha Godavarty, and Eva M. Sevick-Muraca
pp. 211-218
Abstract     Full Text:  [  PDF (362 kB)  ]

Optical fluorescence tomography with the equation of radiative transfer for molecular imaging
Alexander D. Klose and Andreas H. Hielscher
pp. 219-225
Abstract     Full Text:  [  PDF (233 kB)  ]

Optical properties by time-resolved fluorescence Monte Carlo simulation
Praveen Kadimcherla, Mostafa Sadoqi, and Sunil Kumar
pp. 226-235
Abstract     Full Text:  [  PDF (224 kB)  ]

THEORY II

A fast reconstruction algorithm for implementation of time-series DC optical tomography
Yaling Pei, Harry L. Graber, and Randall L. Barbour
pp. 236-245
Abstract     Full Text:  [  PDF (517 kB)  ]

Hybrid DOT and MRI system
Gultekin Gulsen, Ozlem Birgul, and Orhan Nalcioglu
pp. 246-252
Abstract     Full Text:  [  PDF (740 kB)  ]

Reflectance-type image reconstruction algorithm for time-resolved optical tomography of cerebral hemodynamics
Feng Gao, Yukari Tanikawa, Huijuan Zhao, and Yukio Yamada
pp. 253-263
Abstract     Full Text:  [  PDF (406 kB)  ]

Use of MRI information to initialize the first stage of the image reconstruction algorithm in diffuse optical tomography
Murielle Torregrossa, Chantal-Virginie Zint, and Patrick Poulet
pp. 264-272
Abstract     Full Text:  [  PDF (1512 kB)  ]

THEORY III

Fast three-dimensional hybrid-dual-Fourier tomography using a radiative transfer forward model
Wei Cai, Min Xu, and Robert R. Alfano
pp. 273-286
Abstract     Full Text:  [  PDF (270 kB)  ]

Optimizing image reconstruction of tissue blood flow by diffuse correlation tomography
Chao Zhou, Turgut Durduran, Guoqiang Yu, and Arjun G. Yodh
pp. 287-295
Abstract     Full Text:  [  PDF (226 kB)  ]

Internal refractive index changes affect light transport in tissue
Ben A. Brooksby, Hamid Dehghani, Karthik Vishwanath, Brian W. Pogue, and Keith D. Paulsen
pp. 296-304
Abstract     Full Text:  [  PDF (793 kB)  ]

Simulation of spectral reflectance of multiple scattering medium using the Mie theory combined with the Monte Carlo method
Makoto Igarashi, Kazuhiro Gono, Takashi Obi, Masahiro Yamaguchi, and Nagaaki Ohyama
pp. 305-313
Abstract     Full Text:  [  PDF (221 kB)  ]

FLUORESCENCE II

Exogenous specific fluorescence marker location reconstruction using surface fluorescence imaging
Garashi Avital, Israel Gannot, Victor V. Chernomordik, Gallya Gannot, and Amir H. Gandjbakhche
pp. 314-321
Abstract     Full Text:  [  PDF (292 kB)  ]

Determination of subsurface tumor localization in animal models with near-infrared (NIR) fluorescence imaging
Yu Chen, Dana M. Blessington, Zhihong Zhang, Qian Liu, Lanlan Zhou, Chenpeng Mu, Xavier Intes, Samuel I. Achilefu, Hui Li, Min Z. Zhang, Gang Zheng, and Britton Chance
pp. 322-329
Abstract     Full Text:  [  PDF (356 kB)  ]

Estimation of optical fluorescent impulse response kernel in combined time and wavelength spaces
Olga V. Ivanova, Laura Marcu, and Michael C. K. Khoo
pp. 330-341
Abstract     Full Text:  [  PDF (2160 kB)  ]

BREAST III

Assessment of the menstrual cycle upon total hemoglobin, water concentration, and oxygen saturation in the female breast
Shudong Jiang, Brian W. Pogue, Subhadra Srinivasan, Sandra Soho, Steven P. Poplack, Tor D. Tosteson, and Keith D. Paulsen
pp. 342-348
Abstract     Full Text:  [  PDF (258 kB)  ]

Three-dimensional ultrasound imaging system in a combined ultrasound and near-infrared imager
Puyun Guo, Shikui Yan, and Quing Zhu
pp. 349-354
Abstract     Full Text:  [  PDF (382 kB)  ]

OXIMETRY

Quantitative clinical nonpulsatile and localized visible light oximeter: design of the T-Stat tissue oximeter
David A. Benaron, Ilian H. Parachikov, Wai-Fung Cheong, Shai Friedland, Joshua L. Duckworth, David M. Otten, Boris E. Rubinsky, Uwe B. Horchner, Eben L. Kermit, Frank W. Liu, Carl J. Levinson, Aileen L. Murphy, John W. Price, Yair Talmi, and James P. Weersing
pp. 355-368
Abstract     Full Text:  [  PDF (295 kB)  ]

Validation of NIRS in measuring tissue hemoglobin concentration and oxygen saturation on ex vivo and isolated limb models
Xiaorong Xu, Wen Zhu, Vikram Padival, Mengna Xia, Xuefeng Cheng, Robin Bush, Linda Christenson, Tim Chan, Tim Doherty, and Angelo Iatridis
pp. 369-378
Abstract     Full Text:  [  PDF (505 kB)  ]

Noninvasive cerebral hemoglobin oxygenation quantification of fetal sheep under hypoxic stress in utero using frequency-domain diffuse optical two-layer model
Regine Choe, Turgut Durduran, Guoqiang Yu, Mark J. M. Nijland, Peter W. Nathanielsz, Britton Chance, Arjun G. Yodh, and Nirmala Ramanujam
pp. 379-387
Abstract     Full Text:  [  PDF (272 kB)  ]

Nonuniform tumor vascular oxygen dynamics monitored by three-channel near-infrared spectroscopy
Jae G. Kim, Yueqing Gu, Anca Constantinescu, Ralph P. Mason, and Hanli Liu
pp. 388-396
Abstract     Full Text:  [  PDF (450 kB)  ]

Study of the pressure effect in near-infrared spectroscopy
Xuefeng Cheng and Xiaorong Xu
pp. 397-406
Abstract     Full Text:  [  PDF (148 kB)  ]

Validation of hemoglobin and water molar absorption spectra in near-infrared diffuse optical tomography
Subhadra Srinivasan, Brian W. Pogue, Shudong Jiang, Hamid Dehghani, and Keith D. Paulsen
pp. 407-415
Abstract     Full Text:  [  PDF (117 kB)  ]

Breast tumor oxygenation in response to carbogen intervention assessed simultaneously by three oxygen-sensitive parameters
Yueqing Gu, Vincent Bourke, Jae Gwan Kim, Mengna Xia, Anca Constantinescu, Ralph P. Mason, and Hanli Liu
pp. 416-423
Abstract     Full Text:  [  PDF (206 kB)  ]

MUSCLE

Eight-channel time-resolved tissue oximeter for functional muscle studies
Rinaldo Cubeddu, Giovanni Biscotti, Antonio Pifferi, Paola Taroni, Alessandro Torricelli, Marco Ferrari, and Valentina Quaresima
pp. 424-430
Abstract     Full Text:  [  PDF (154 kB)  ]

Clinical evaluation of a near-infrared tissue spectrometer in peripheral vascular disease
Xuefeng Cheng, Jian-Min Mao, Xiaorong Xu, Mohamed Elmandjra, Robin Bush, Linda Christenson, Bill O'Keefe, and John Bry
pp. 431-436
Abstract     Full Text:  [  PDF (453 kB)  ]

NIR time domain diffuse optical tomography experiments on human forearm
Huijuan Zhao, Feng Gao, Yukari Tanikawa, Kazuhiro Homma, and Yukio Yamada
pp. 437-446
Abstract     Full Text:  [  PDF (438 kB)  ]

Quantification of muscle oxygenation and flow of healthy volunteers during cuff occlusion of arm and leg flexor muscles and plantar flexion exercise
Turgut Durduran, Guoqiang Yu, Chao Zhou, Gwen Lech, Britton Chance, and Arjun G. Yodh
pp. 447-453
Abstract     Full Text:  [  PDF (239 kB)  ]

RSI: oxygen consumption, blood flow, and reoxygenation in patients suffering RSI measured by noninvasive optical spectroscopy
Dick H. J. Thijssen, Caro J. T. van Uden, Hans Krijgsman, and Willy N. J. M. Colier
pp. 454-461
Abstract     Full Text:  [  PDF (416 kB)  ]

INSTRUMENTATION II

Angular domain optical imaging of structures within highly scattering material using silicon micromachined collimating arrays
Glenn H. Chapman, Maria Trinh, Desmond Lee, Nick Pfeiffer, and Gary Chu
pp. 462-473
Abstract     Full Text:  [  PDF (1495 kB)  ]

Spread spectrum time-resolved photon migration imaging system: the principle and simulation results
Nan Guang Chen and Quing Zhu
pp. 474-479
Abstract     Full Text:  [  PDF (65 kB)  ]

Analysis of ICCD time-gated images through turbid media using a perturbative model
Cosimo D'Andrea, Daniela Comelli, Gianluca Valentini, and Rinaldo Cubeddu
pp. 480-486
Abstract     Full Text:  [  PDF (838 kB)  ]

Optical fiber arrangement of optical topography for spatial resolution improvement
Tsuyoshi Yamamoto, Eiji Okada, Fumio Kawaguchi, Atsushi Maki, Yukio Yamada, and Hideaki Koizumi
pp. 487-496
Abstract     Full Text:  [  PDF (223 kB)  ]

FLUORESENCE III

Detection and imaging of the reconstituted pyropheophorbide-cholesterol oleate labeled low-density lipoprotein in the HepG2 tumor
Dana M. Blessington, Zhihong Zhang, Hui Li, Min Zhang, Lanlan Zhou, Jerry D. Glickson, Gang Zheng, and Britton Chance
pp. 497-504
Abstract     Full Text:  [  PDF (472 kB)  ]

NIR imaging the delivery of cathespin B probe to breast tumors
Lanlan Zhou, Dana M. Blessington, Zhihong Zhang, Aristid E. Lindenmayer, Ching H. Tung, Ralph Weissleder, and Britton Chance
pp. 505-512
Abstract     Full Text:  [  PDF (404 kB)  ]

POSTERS

Imaging small inhomogeneities by time-resolved laser transmittance measurements using different reconstruction procedures
Rosario Esposito, Maria Lepore, Ines Delfino, and Pietro L. Indovina
pp. 513-520
Abstract     Full Text:  [  PDF (336 kB)  ]

Spatiotemporal characteristics of cerebral blood volume changes in different microvascular compartments evoked by sciatic nerve stimulation in rat somatosensory cortex
Pengcheng Li, Qingming Luo, Weihua Luo, Shanbin Chen, Haiying Cheng, and Shaoqun Zeng
pp. 521-529
Abstract     Full Text:  [  PDF (390 kB)  ]

Retrieval of the optical properties of a layered medium based on an exact analytical solution of the time-dependent diffusion equation
Fabrizio Martelli, Samuele del Bianco, Angelo Sassaroli, and Giovanni Zaccanti
pp. 530-535
Abstract     Full Text:  [  PDF (114 kB)  ]

Random walk analysis of time-resolved transmittance measurements
Ines Delfino, Maria Lepore, and Pietro L. Indovina
pp. 536-545
Abstract     Full Text:  [  PDF (181 kB)  ]

Biochemical changes between normal and BCC tissue: a FT-Raman study
Lilian de Oliveira Nunes, Airton A. Martin, Landulfo Silveira, Jr., Marcelo Zampieri, and Egberto Munin
pp. 546-553
Abstract     Full Text:  [  PDF (72 kB)  ]

The way to universal and correct medical presentation of diagnostic informations for complex spectrophotometry noninvasive medical diagnostic systems
Dmitrii A. Rogatkin and Vladimir V. Tchernyi
pp. 554-558
Abstract     Full Text:  [  PDF (77 kB)  ]

Detection of time window of cerebral blood flow response induced by sciatic nerve stimulation using temporal clustering analysis
Zheng Wang, Qingming Luo, Haiying Cheng, and Shaoqun Zeng
pp. 559-566
Abstract     Full Text:  [  PDF (208 kB)  ]

Quantitative estimate of spatial/temporal variations in the optical properties of tissue-like media from diffuse reflectance data
Francesco Fabbri, Maria-Angela Franceschini, and Sergio Fantini
pp. 567-574
Abstract     Full Text:  [  PDF (164 kB)  ]

Application of I&Q detection system in scouting the curative effect of neck squamous cell carcinoma
Jun Zhang, Tao Tu, Ulas Sunar, Xavier Intes, Shoko Nioka, Zhihong Zhang, Alex Kilger, Robert A. Lustig, Laurie A. Loevner, and Britton Chance
pp. 575-580
Abstract     Full Text:  [  PDF (139 kB)  ]

Spatial sensitivity profiles by time-resolved fluorescence Monte Carlo simulation
Praveen Kadimcherla, Mostafa Sadoqi, and Sunil Kumar
pp. 581-590
Abstract     Full Text:  [  PDF (356 kB)  ]

Hybrid approach to Bayesian image reconstruction
Chaoyang Zhang, Margaret J. Eppstein, Anuradha Godavarty, and Eva M. Sevick-Muraca
pp. 591-599
Abstract     Full Text:  [  PDF (388 kB)  ]

Effects of tissue optical properties on time-resolved fluorescence measurements from brain tumors: an experimental and computational study
Pramod V. Butte, Karthik Vishwanath, Brian K. Pikul, Mary-Ann Mycek, and Laura Marcu
pp. 600-608
Abstract     Full Text:  [  PDF (155 kB)  ]

Method to measure the optical properties of small volumes of biological tissues
Fabrizio Martelli, Samuele del Bianco, and Giovanni Zaccanti
pp. 609-614
Abstract     Full Text:  [  PDF (187 kB)  ]

Finger joint imaging by laser transillumination computed tomography based on coherent detection imaging method
Shinji Tanosaki, Yoshiaki Sasaki, Michiaki Takagi, Akira Ishikawa, Jota Suzuki, Ryota Emori, Hiroki Inage, Tetsuya Yuasa, Hiroshi Taniguchi, Balasigamani Devaraj, and Takao Akatsuka
pp. 615-623
Abstract     Full Text:  [  PDF (509 kB)  ]

Modeling photon propagation in anisotropically scattering media with the equation of radiative transfer
Alexander D. Klose and Andreas H. Hielscher
pp. 624-633
Abstract     Full Text:  [  PDF (396 kB)  ]

Diffuse optical tomography with a priori anatomical information
Murat Guven, Birsen Yazici, Xavier Intes, and Britton Chance
pp. 634-646
Abstract     Full Text:  [  PDF (366 kB)  ]

Three-dimensional imaging of the metabolic state of c-MYC-induced mammary tumor with the cryo-imager
Zhihong Zhang, Qian Liu, Qingming Luo, Min Z. Zhang, Dana M. Blessington, Lanlan Zhou, Lewis A. Chodosh, Gang Zheng, and Britton Chance
pp. 647-655
Abstract     Full Text:  [  PDF (584 kB)  ]

Handheld low-frequency phased array near-infrared (NIR) breast cancer localizer
Qian Liu, Yu Chen, and Qingming Luo
pp. 656-663
Abstract     Full Text:  [  PDF (304 kB)  ]