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EDITORIAL

From the New Editor-in-Chief
Lihong V. Wang
J. Biomed. Opt. Vol. 15, 010101 (Feb. 18, 2010)
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JBO LETTERS

High-speed spectral domain polarization- sensitive optical coherence tomography using a single camera and an optical switch at 1.3  µm
Sang-Won Lee, Hyun-Woo Jeong, and Beop-Min Kim
J. Biomed. Opt. Vol. 15, 010501 (Jan. 11, 2010)
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Single sensor that outputs narrowband multispectral images
Linghua Kong, Dingrong Yi, Stephen Sprigle, Fengtao Wang, Chao Wang, Fuhan Liu, Ali Adibi, and Rao Tummala
J. Biomed. Opt. Vol. 15, 010502 (Jan. 7, 2010)
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Imaging morphogenesis of Candida albicans during infection in a live animal
Soumya Mitra, Kristy Dolan, Thomas H. Foster, and Melanie Wellington
J. Biomed. Opt. Vol. 15, 010504 (Jan. 13, 2010)
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Quantitative phase microscopy of articular chondrocyte dynamics by wide-field digital interferometry
Natan T. Shaked, John D. Finan, Farshid Guilak, and Adam Wax
J. Biomed. Opt. Vol. 15, 010505 (Jan. 29, 2010)
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Structured illumination enhances resolution and contrast in thick tissue fluorescence imaging
Amaan Mazhar, David J. Cuccia, Sylvain Gioux, Anthony J. Durkin, John V. Frangioni, and Bruce J. Tromberg
J. Biomed. Opt. Vol. 15, 010506 (Mar. 2, 2010)
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Real-time photoacoustic tomography of cortical hemodynamics in small animals
Changhui Li, Andres Aguirre, John Gamelin, Anastasios Maurudis, Quing Zhu, and Lihong V. Wang
J. Biomed. Opt. Vol. 15, 010509 (Feb. 16, 2010)
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Multifunctional microbubbles and nanobubbles for photoacoustic and ultrasound imaging
Chulhong Kim, Ruogu Qin, Jeff S. Xu, Lihong V. Wang, and Ronald Xu
J. Biomed. Opt. Vol. 15, 010510 (Feb. 18, 2010)
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Integrated intravascular optical coherence tomography ultrasound imaging system
Jiechen Yin, Hao-Chung Yang, Xiang Li, Jun Zhang, Qifa Zhou, Changhong Hu, K. Kirk Shung, and Zhongping Chen
J. Biomed. Opt. Vol. 15, 010512 (Feb. 18, 2010)
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Spectral areas and ratios classifier algorithm for pancreatic tissue classification using optical spectroscopy
Malavika Chandra, James Scheiman, Diane Simeone, Barbara McKenna, Julianne Purdy, and Mary-Ann Mycek
J. Biomed. Opt. Vol. 15, 010514 (Feb. 18, 2010)
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GUEST EDITORIAL

Guest Editorial: Optical Methods in Vascular Biology and Medicine
Bernard Choi, Brett Bouma, Dai Fukumura, and Rakesh K. Jain
J. Biomed. Opt. Vol. 15, 011001 (Mar. 2, 2010)
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SPECIAL SECTION ON OPTICAL METHODS IN VASCULAR BIOLOGY AND MEDICINE

Photoacoustic imaging and characterization of the microvasculature
Song Hu and Lihong V. Wang
J. Biomed. Opt. Vol. 15, 011101 (Jan. 21, 2010)
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Functional optical imaging at the microscopic level
Beatriz Y. Salazar Vázquez, Ciel Makena Hightower, Francesca Sapuppo, Daniel M. Tartakovsky, and Marcos Intaglietta
J. Biomed. Opt. Vol. 15, 011102 (Jan. 11, 2010)
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Doppler optical coherence tomography for interventional cardiovascular guidance: in vivo feasibility and forward-viewing probe flow phantom demonstration
Nigel R. Munce, Graham A. Wright, Adrian Mariampillai, Beau A. Standish, Michael K. K. Leung, Louis Tan, Kenneth Lee, Brian K. Courtney, Aaron A. Teitelbaum, Bradley H. Strauss, I. Alex Vitkin, and Victor X. D. Yang
J. Biomed. Opt. Vol. 15, 011103 (Jan. 19, 2010)
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Challenges on the frontier of intracoronary imaging: atherosclerotic plaque macrophage measurement by optical coherence tomography
Atsushi Tanaka, Guillermo J. Tearney, and Brett E. Bouma
J. Biomed. Opt. Vol. 15, 011104 (Mar. 2, 2010)
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Atherosclerotic tissue characterization in vivo by optical coherence tomography attenuation imaging
Gijs van Soest, Thadé Goderie, Evelyn Regar, Senada Koljenović, Geert L. J. H. van Leenders, Nieves Gonzalo, Sander van Noorden, Takayuki Okamura, Brett E. Bouma, Guillermo J. Tearney, J. Wolter Oosterhuis, Patrick W. Serruys, and Anton F. W. van der Steen
J. Biomed. Opt. Vol. 15, 011105 (Jan. 15, 2010)
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Fluorescence lifetime in cardiovascular diagnostics
Laura Marcu
J. Biomed. Opt. Vol. 15, 011106 (Mar. 1, 2010)
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Intravascular near-infrared fluorescence molecular imaging of atherosclerosis: toward coronary arterial visualization of biologically high-risk plaques
Marcella A. Calfon, Claudio Vinegoni, Vasilis Ntziachristos, and Farouc A. Jaffer
J. Biomed. Opt. Vol. 15, 011107 (Jan. 14, 2010)
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In vivo high-resolution structural imaging of large arteries in small rodents using two-photon laser scanning microscopy
Remco T. A. Megens, Sietze Reitsma, Lenneke Prinzen, Mirjam G. A. oude Egbrink, Wim Engels, Peter J. A. Leenders, Ellen J. L. Brunenberg, Koen D. Reesink, Ben J. A. Janssen, Bart M. ter Haar Romeny, Dick W. Slaaf, and Marc A. M. J. van Zandvoort
J. Biomed. Opt. Vol. 15, 011108 (Jan. 25, 2010)
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Laser speckle contrast imaging in biomedical optics
David A. Boas and Andrew K. Dunn
J. Biomed. Opt. Vol. 15, 011109 (Jan. 13, 2010)
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Magnetomotive laser speckle imaging
Jeehyun Kim, Junghwan Oh, and Bernard Choi
J. Biomed. Opt. Vol. 15, 011110 (Jan. 13, 2010)
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Spectral imaging reveals microvessel physiology and function from anastomoses to thromboses
Mamta Wankhede, Nikita Agarwal, Rodrigo A. Fraga-Silva, Casey deDeugd, Mohan K. Raizada, S. Paul Oh, and Brian S. Sorg
J. Biomed. Opt. Vol. 15, 011111 (Feb. 19, 2010)
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Longitudinal optical imaging of tumor metabolism and hemodynamics
Melissa C. Skala, Andrew Fontanella, Lan Lan, Joseph A. Izatt, and Mark W. Dewhirst
J. Biomed. Opt. Vol. 15, 011112 (Jan. 13, 2010)
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Application of intravital microscopy in studies of tumor microcirculation
Sarah Jane Lunt, Colin Gray, Constantino Carlos Reyes-Aldasoro, Stephen J. Matcher, and Gillian M. Tozer
J. Biomed. Opt. Vol. 15, 011113 (Feb. 9, 2010)
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Evaluation of hypericin-mediated photodynamic therapy in combination with angiogenesis inhibitor bevacizumab using in vivo fluorescence confocal endomicroscopy
Ramaswamy Bhuvaneswari, Patricia S. P. Thong, Yik-Yuen Gan, Khee Soo, and Malini Olivo
J. Biomed. Opt. Vol. 15, 011114 (Jan. 25, 2010)
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RESEARCH PAPERS: GENERAL

Special method to prepare quantum dot probes with reduced cytotoxicity and increased optical property
Hai-Li Zhang, Yong-Qiang Li, Jian-Hao Wang, Xiang-Ning Li, Song Lin, Yuan-Di Zhao, and Qing-Ming Luo
J. Biomed. Opt. Vol. 15, 015001 (Jan. 25, 2010)
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Epidermal laser stimulation of action potentials in the frog sciatic nerve
Nichole M. Jindra, Douglas Goddard, Michelle Imholte, and Robert J. Thomas
J. Biomed. Opt. Vol. 15, 015002 (Feb. 4, 2010)
Abstract     Full Text:  [  HTML   Sectioned HTML    PDF (435 kB)  ]

Efficient mucosal delivery of optical contrast agents using imidazole-modified chitosan
Bilal Ghosn, Anne L. van de Ven, Justina Tam, Ann Gillenwater, Konstantin V. Sokolov, Rebecca Richards-Kortum, and Krishnendu Roy
J. Biomed. Opt. Vol. 15, 015003 (Feb. 19, 2010)
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Linking optics and mechanics in an in vivo model of airway fibrosis and epithelial injury
Christopher B. Raub, Sari Mahon, Navneet Narula, Bruce J. Tromberg, Matthew Brenner, and Steven C. George
J. Biomed. Opt. Vol. 15, 015004 (Feb. 22, 2010)
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Use of optical tweezers to probe epithelial mechanosensation
Andrew Resnick
J. Biomed. Opt. Vol. 15, 015005 (Feb. 18, 2010)
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Label-free optical control of arterial contraction
Myunghwan Choi, Jonghee Yoon, and Chulhee Choi
J. Biomed. Opt. Vol. 15, 015006 (Feb. 23, 2010)
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Investigating the spectral characteristics of backscattering from heterogeneous spherical nuclei using broadband finite-difference time-domain simulations
Guo-Shan Chao and Kung-Bin Sung
J. Biomed. Opt. Vol. 15, 015007 (Feb. 24, 2010)
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RESEARCH PAPERS: IMAGING

Ex vivo imaging of human thyroid pathology using integrated optical coherence tomography and optical coherence microscopy
Chao Zhou, Yihong Wang, Aaron D. Aguirre, Tsung-Han Tsai, David W. Cohen, James L. Connolly, and James G. Fujimoto
J. Biomed. Opt. Vol. 15, 016001 (Feb. 22, 2010)
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Calcium imaging of inner ear hair cells within the cochlear epithelium of mice using two-photon microscopy
Tao Yuan, Simon S. Gao, Peter Saggau, and John S. Oghalai
J. Biomed. Opt. Vol. 15, 016002 (Jan. 20, 2010)
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Spatiotemporal laser speckle contrast analysis for blood flow imaging with maximized speckle contrast
Jianjun Qiu, Pengcheng Li, Weihua Luo, Jia Wang, Hongyan Zhang, and Qingming Luo
J. Biomed. Opt. Vol. 15, 016003 (Jan. 15, 2010)
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Real-time and high-performance calibration method for high-speed swept-source optical coherence tomography
Ehsan Azimi, Bin Liu, and Mark E. Brezinski
J. Biomed. Opt. Vol. 15, 016005 (Jan. 28, 2010)
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Real-time diffuse optical tomography based on structured illumination
Samuel Bélanger, Maxime Abran, Xavier Intes, Christian Casanova, and Frédéric Lesage
J. Biomed. Opt. Vol. 15, 016006 (Jan. 15, 2010)
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Multistage inversion algorithm for biological tissue imaging
Krishna Agarwal, Ling Chen, Nanguang Chen, and Xudong Chen
J. Biomed. Opt. Vol. 15, 016007 (Jan. 13, 2010)
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Fluorescence lifetime dynamics of enhanced green fluorescent protein in protein aggregates with expanded polyglutamine
Vladimir Ghukasyan, Chih-Chun Hsu, Chia-Rung Liu, Fu-Jen Kao, and Tzu-Hao Cheng
J. Biomed. Opt. Vol. 15, 016008 (Jan. 15, 2010)
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Application of optical coherence tomography to automated contact lens metrology
Bryan R. Davidson and Jennifer K. Barton
J. Biomed. Opt. Vol. 15, 016009 (Jan. 20, 2010)
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Enhanced photoacoustic stability of gold nanorods by silica matrix confinement
Leng-Chun Chen, Chen-Wei Wei, Jeffrey S. Souris, Shih-Hsun Cheng, Chin-Tu Chen, Chung-Shi Yang, Pai-Chi Li, and Leu-Wei Lo
J. Biomed. Opt. Vol. 15, 016010 (Feb. 1, 2010)
Abstract     Full Text:  [  HTML   Sectioned HTML    PDF (670 kB)  ]

DLP^TM-based dichoptic vision test system
Russell L. Woods, Henry L. Apfelbaum, and Eli Peli
J. Biomed. Opt. Vol. 15, 016011 (Feb. 16, 2010)
Abstract     Full Text:  [  HTML   Sectioned HTML    PDF (1570 kB)  ]

Fluorescence imaging of vascular endothelial growth factor in tumors for mice embedded in a turbid medium
Nrusingh C. Biswal, John K. Gamelin, Baohong Yuan, Marina V. Backer, Joseph M. Backer, and Quing Zhu
J. Biomed. Opt. Vol. 15, 016012 (Feb. 18, 2010)
Abstract     Full Text:  [  HTML   Sectioned HTML    PDF (651 kB)  ]

Microcomputer-based artificial vision support system for real-time image processing for camera-driven visual prostheses
Wolfgang Fink, Cindy X. You, and Mark A. Tarbell
J. Biomed. Opt. Vol. 15, 016013 (Jan. 25, 2010)
Abstract     Full Text:  [  HTML   Sectioned HTML    PDF (392 kB)  ]

Rapid convergence to the inverse solution regularized with Lorentzian distributed function for near-infrared continuous wave diffuse optical tomography
Min-Cheng Pan and Min-Chun Pan
J. Biomed. Opt. Vol. 15, 016014 (Feb. 19, 2010)
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Relative capacities of time-gated versus continuous-wave imaging to localize tissue embedded vessels with increasing depth
Nimit L. Patel, Zi-Jing Lin, Yajuvendra Rathore, Edward H. Livingston, Hanli Liu, and George Alexandrakis
J. Biomed. Opt. Vol. 15, 016015 (Feb. 4, 2010)
Abstract     Full Text:  [  HTML   Sectioned HTML    PDF (813 kB)  ]

Fluorescence diffuse optical tomography for free-space and multifluorophore studies
Anne Koenig, Lionel Hervé, Georges Gonon, Véronique Josserand, Michel Berger, Jean-Marc Dinten, Jérôme Boutet, Philippe Peltié, Jean-Luc Coll, and Philippe Rizo
J. Biomed. Opt. Vol. 15, 016016 (Mar. 1, 2010)
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Detection of vesicant-induced upper airway mucosa damage in the hamster cheek pouch model using optical coherence tomography
Marie J. Hammer-Wilson, Vi Nguyen, Woong-Gyu Jung, Yehchen Ahn, Zhongping Chen, and Petra Wilder-Smith
J. Biomed. Opt. Vol. 15, 016017 (Feb. 18, 2010)
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Screening small-molecule compound microarrays for protein ligands without fluorescence labeling with a high-throughput scanning microscope
Yiyan Fei, James P. Landry, Yungshin Sun, Xiangdong Zhu, Xiaobing Wang, Juntao Luo, Chun-Yi Wu, and Kit S. Lam
J. Biomed. Opt. Vol. 15, 016018 (Feb. 18, 2010)
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Photoacoustic discrimination of vascular and pigmented lesions using classical and Bayesian methods
Jennifer A. Swearingen, Scott H. Holan, Mary M. Feldman, and John A. Viator
J. Biomed. Opt. Vol. 15, 016019 (Mar. 1, 2010)
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Two-photon intravital imaging of thrombus development
Malgorzata M. Kamocka, Jian Mu, Xiaomin Liu, Nan Chen, Amy Zollman, Barbara Sturonas-Brown, Kenneth Dunn, Zhiliang Xu, Danny Z. Chen, Mark S. Alber, and Elliot D. Rosen
J. Biomed. Opt. Vol. 15, 016020 (Feb. 23, 2010)
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Detection of retinal nerve fiber layer defects on retinal fundus images for early diagnosis of glaucoma
Chisako Muramatsu, Yoshinori Hayashi, Akira Sawada, Yuji Hatanaka, Takeshi Hara, Tetsuya Yamamoto, and Hiroshi Fujita
J. Biomed. Opt. Vol. 15, 016021 (Feb. 23, 2010)
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Angular domain fluorescence imaging for small animal research
Fartash Vasefi, Michelle Belton, Bozena Kaminska, Glenn H. Chapman, and Jeffrey J. L. Carson
J. Biomed. Opt. Vol. 15, 016023 (Jan. 20, 2010)
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Adaptation and focusing of optode configurations for fluorescence optical tomography by experimental design methods
Manuel Freiberger, Christian Clason, and Hermann Scharfetter
J. Biomed. Opt. Vol. 15, 016024 (Mar. 2, 2010)
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Cellular resolution ex vivo imaging of gastrointestinal tissues with optical coherence microscopy
Aaron D. Aguirre, Yu Chen, Bradley Bryan, Hiroshi Mashimo, Qin Huang, James L. Connolly, and James G. Fujimoto
J. Biomed. Opt. Vol. 15, 016025 (Mar. 2, 2010)
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Scanning light-sheet microscopy in the whole mouse brain with HiLo background rejection
Jerome Mertz and Jinhyun Kim
J. Biomed. Opt. Vol. 15, 016027 (Feb. 24, 2010)
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New, simple theory-based, accurate polarization microscope for birefringence imaging of biological cells
In Hee Shin, Sang-Mo Shin, and Dug Young Kim
J. Biomed. Opt. Vol. 15, 016028 (Mar. 3, 2010)
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Doppler variance imaging for three-dimensional retina and choroid angiography
Lingfeng Yu and Zhongping Chen
J. Biomed. Opt. Vol. 15, 016029 (Feb. 16, 2010)
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Three-dimensional Fourier domain optical coherence tomography in vivo imaging of alveolar tissue in the intact thorax using the parietal pleura as a window
Sven Meissner, Lilla Knels, Christian Schnabel, Thea Koch, and Edmund Koch
J. Biomed. Opt. Vol. 15, 016030 (Feb. 9, 2010)
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RESEARCH PAPERS: SENSING

Comparison of cobinamide to hydroxocobalamin in reversing cyanide physiologic effects in rabbits using diffuse optical spectroscopy monitoring
Matthew Brenner, Sari B. Mahon, Jangwoen Lee, Jae Kim, David Mukai, Seth Goodman, Kelly A. Kreuter, Rebecca Ahdout, Othman Mohammad, Vijay S. Sharma, William Blackledge, and Gerry R. Boss
J. Biomed. Opt. Vol. 15, 017001 (Jan. 13, 2010)
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Real-time, closed-loop dual-wavelength optical polarimetry for glucose monitoring
Bilal H. Malik and Gerard L. Coté
J. Biomed. Opt. Vol. 15, 017002 (Jan. 11, 2010)
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Temperature-dependent optical properties of Intralipid^® measured with frequency-domain photon-migration spectroscopy
Biju Cletus, Rainer Künnemeyer, Paul Martinsen, and Vincent Andrew McGlone
J. Biomed. Opt. Vol. 15, 017003 (Jan. 15, 2010)
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Integration of single-fiber reflectance spectroscopy into ultrasound-guided endoscopic lung cancer staging of mediastinal lymph nodes
Stephen Chad Kanick, Cor van der Leest, Joachim G. J. V. Aerts, Henk C. Hoogsteden, Slávka Kaščáková, Henricus J. C. M. Sterenborg, and Arjen Amelink
J. Biomed. Opt. Vol. 15, 017004 (Jan. 15, 2010)
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Highly sensitive optical detection of specific protein in breast cancer cells using microstructured fiber in extremely low sample volume
Saraswathi Padmanabhan, Vengalathunadakal K. Shinoj, Vadakke M. Murukeshan, and Parasuraman Padmanabhan
J. Biomed. Opt. Vol. 15, 017005 (Feb. 16, 2010)
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Hardware implementation algorithm and error analysis of high-speed fluorescence lifetime sensing systems using center-of-mass method
Day-Uei Li, Bruce Rae, Robin Andrews, Jochen Arlt, and Robert Henderson
J. Biomed. Opt. Vol. 15, 017006 (Feb. 16, 2010)
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Comparisons of muscle oxygenation changes between arm and leg muscles during incremental rowing exercise with near-infrared spectroscopy
Zhongxing Zhang, Bangde Wang, Hui Gong, Guodong Xu, Shoko Nioka, and Britton Chance
J. Biomed. Opt. Vol. 15, 017007 (Feb. 19, 2010)
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Reliability of near-infrared spectroscopy for measuring biceps brachii oxygenation during sustained and repeated isometric contractions
Makii Muthalib, Guillaume Y. Millet, Valentina Quaresima, and Kazunori Nosaka
J. Biomed. Opt. Vol. 15, 017008 (Feb. 18, 2010)
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Discrimination analysis of human lung cancer cells associated with histological type and malignancy using Raman spectroscopy
Yusuke Oshima, Hideyuki Shinzawa, Tatsuji Takenaka, Chie Furihata, and Hidetoshi Sato
J. Biomed. Opt. Vol. 15, 017009 (Feb. 18, 2010)
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In vivo native fluorescence spectroscopy and nicotinamide adinine dinucleotide/flavin adenine dinucleotide reduction and oxidation states of oral submucous fibrosis for chemopreventive drug monitoring
Shanmugam Sivabalan, C. Ponranjini Vedeswari, Sadaksharam Jayachandran, Dornadula Koteeswaran, Chidambaranathan Pravda, Prakasa Rao Aruna, and Singaravelu Ganesan
J. Biomed. Opt. Vol. 15, 017010 (Mar. 2, 2010)
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Kinetics of a single cross-bridge in familial hypertrophic cardiomyopathy heart muscle measured by reverse Kretschmann fluorescence
Prasad Mettikolla, Nils Calander, Rafal Luchowski, Ignacy Gryczynski, Zygmunt Gryczynski, and Julian Borejdo
J. Biomed. Opt. Vol. 15, 017011 (Mar. 2, 2010)
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Determination of optical properties of turbid media spanning visible and near-infrared regimes via spatially modulated quantitative spectroscopy
Rolf B. Saager, David J. Cuccia, and Anthony J. Durkin
J. Biomed. Opt. Vol. 15, 017012 (Feb. 9, 2010)
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RESEARCH PAPERS: THERAPEUTIC

Photothermal therapy in a murine colon cancer model using near-infrared absorbing gold nanorods
Glenn P. Goodrich, LiLi Bao, Kelly Gill-Sharp, Krystina L. Sang, James Wang, and J. Donald Payne
J. Biomed. Opt. Vol. 15, 018001 (Jan. 15, 2010)
Abstract     Full Text:  [  HTML   Sectioned HTML    PDF (355 kB)  ]

Preferential accumulation of 5-aminolevulinic acid-induced protoporphyrin IX in breast cancer: a comprehensive study on six breast cell lines with varying phenotypes
Stacy R. Millon, Julie H. Ostrander, Siavash Yazdanfar, J. Quincy Brown, Janelle E. Bender, Anita Rajeha, and Nirmala Ramanujam
J. Biomed. Opt. Vol. 15, 018002 (Feb. 18, 2010)
Abstract     Full Text:  [  HTML   Sectioned HTML    PDF (372 kB)  ]

Optical, thermal, and electrical monitoring of radio-frequency tissue modification
Timmy Floume, Richard R. A. Syms, Ara W. Darzi, and George B. Hanna
J. Biomed. Opt. Vol. 15, 018003 (Feb. 24, 2010)
Abstract     Full Text:  [  HTML   Sectioned HTML    PDF (696 kB)  ]

ERRATA

Errata: Two-photon microscope for multisite microphotolysis of caged neurotransmitters in acute brain slices
Bradley E. Losavio, Vijay Iyer, and Peter Saggau
J. Biomed. Opt. Vol. 15, 019801 (Feb. 24, 2010)
Abstract     Full Text:  [  HTML   Sectioned HTML    PDF (42 kB)  ]